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A 2-years triple-blind Randomized Clinical Trial on the efficacy of H.A.F. / 22F-010

16:30 - 17:30 (GMT+03:00)
13 May 2022
Lecture
Add to calendar 05/13/2022 16:30 05/13/2022 17:30 Europe/Bucharest A 2-years triple-blind Randomized Clinical Trial on the efficacy of H.A.F. / 22F-010 - International Conference of Esthetic Dentistry

Speakers:
Guglielmo Giuseppe Campus, Switzerland

Click here to view more details about this session.
J.W. Marriott Bucharest Grand Hotel contact@escdonline.eu aKyOfPFEVzRHclXpWmTW75232

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Although preventable, dental caries is one of the most prevalent chronic disease among children worldwide, and the most common unmet healthcare need among disadvantage children. Fluoride (usually via toothpaste) has the most consistent benefit in preventing caries development and re- mineralizing initial lesions. One of the new caries remineralizing technologies is the synthetic hydroxyapatite (HA) (Ca10(PO4)3(OH)2) as a bioactive-compatible material with similar chemical composition to the apatite crystals of human enamel, inserted as micro-cluster or nanocrystalline forms in different oral care products. A toothpaste containing ion-doped hydroxyapatite (Sr-Mg- CO3-HA) and HA partially substituted with fluoride (HAF) embedded in a chitosan matrix showed, in-vitro, a promising capacity of restore demineralized enamel.

In this conference, we would like to present the data of a recent RCT aimed to compare the caries preventive efficacy of toothpastes containing fluoride biomimetic hydroxyapatite (HA) complex compared to sodium monofluorophosphate fluoridated toothpastes in schoolchildren. Four toothpastes, two containing fluoride-substituted hydroxyapatite (H.A.F.) (1000 and 1450 ppmF) and two Mono fluoridated toothpastes (1000 and 1450 ppmF) were randomly administered during 24 months to two younger children groups (Gyoung) and to two older children groups (Gold). ICDAS was used to score lesions as initial, moderate and severe. Caries examination was repeated at 12 and 24 months. The efficacy of the treatment was assessed as the reduction in risk ratio (RR) and the number needed to treat (NNT).

Results; 518 patients (Gyoung=268; Gold=250) concluded the trial. The caries increment at 24-month evaluation was statistically lower in the primary dentition in the H.A.F. arms versus the traditional fluoridated arms (0.18 vs 0.27 p=0.04 in Gyoung and 0.16 vs 0.30 p=0.01 in Gold for severe lesions). In the permanent dentition, caries increase was statistically lower in the H.A.F. arm, both for initial and severe lesions (0.09 vs 0.17 p=0.02 and 0.18 vs 0.28 p=0.01, respectively). In primary dentition, children receiving H.A.F. Toothpaste had a RR of 39% (Gyoung), a NNT of 3.97 and a RR of 38% and NNT of 4.43 (Gold), compared to children receiving traditional Toothpastes. The RR in the permanent dentition was 29% in children treated with H.A.F. toothpaste; while NNT was 5.68.

Conclusions. Toothpastes with new compounds with remineralizing and antibacterial properties might contribute together with fluoride to reduce a dental caries.

Guglielmo Giuseppe Campus
Guglielmo Giuseppe Campus
Switzerland



Guglielmo Campus was nominated Extraordinariat Professor fur Präventivzahnmedizin und Orale Epidemiologie starting from February the 1st, 2019. He began his training at the Dental school, University of Sassari where he received his degree. He is Associate Professor Community Dentistry, Cariology and Paeditric Dentistry, University of Sassari since 2014. He is also Coordinator of the Italian WHO Collaborating Center (WHO CC) for Epidemiology and Community Dentistry. Research interests are largely direct towards Oral Epidemiology, Community Dentistry, Preventive Dentistry, Cariology and Paediatric Dentistry. During the years research interests span from Public Health Dentistry, Community Dentistry, Paediatric Dentistry, Restorative materials and Preventive programs. He is Member of the Research Board within The Italian Minister of Health for the realization of the Italian National Guidelines for Caries prevention and of the Clinical recommendations in Paediatric Dentistry. Dr. Campus is authors of more than 180 scientific papers. His work inside the WHO CC is to plan, to coordinate the assessing of oral health conditions of populations, policies development and implementation in Italy and other countries like Burkina Faso, Mexico etc; to support the early implementation of the phase down use of dental amalgam in the context of the Minamata Convention and Universal Health coverage (UHC) in Italy; to support measure that encourage life-course approach and population-based strategies related to reducing sugar consumption, tobacco control and affordability of fluoride-containing toothpaste and others vehicles of fluoride.



Guglielmo Giuseppe Campus' sessions:

16:30 - 17:30 (GMT)
May 13, 2022
Lecture
Add to calendar 05/13/2022 16:30 05/13/2022 17:30 A 2-years triple-blind Randomized Clinical Trial on the efficacy of H.A.F. / 22F-010 - International Conference of Esthetic Dentistry

Speakers:
Guglielmo Giuseppe Campus, Switzerland

Click here to view more details about this session.
J.W. Marriott Bucharest Grand Hotel contact@escdonline.eu aKyOfPFEVzRHclXpWmTW75232


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A 2-years triple-blind Randomized Clinical Trial on the efficacy of H.A.F. / 22F-010
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